As I stood in my kitchen, the enticing aroma of melting cheese and savory chicken wafted through the air, pulling my family in like moths to a flame. My go-to weeknight comfort dish? The Chicken Bubble Biscuit Bake Casserole! This easy and customizable recipe is not only a crowd-pleaser, but it’s also perfect for busy evenings when time is tight. Combining tender chicken, fluffy biscuit dumplings, and a creamy sauce, it’s a dish that hugs you from the inside out. Plus, it’s kid-friendly and can be thrown together in no time, making it an ideal choice for potlucks or simply a cozy family dinner. Ready to dive into a warm bowl of comfort? Let’s get cooking!

Why is This Casserole So Irresistible?
Comforting and satisfying, the Chicken Bubble Biscuit Bake Casserole is a hug in a bowl! Quick preparation means you can whip this up even on the busiest nights. Versatile enough to customize with your favorite add-ins, like a cheesy ranch twist or veggie boost, it caters to everyone’s tastes. Kid-approved, it’s a guaranteed hit for family dinners and casual potlucks alike. For other comforting options, check out my Southern Cheesy Chicken or Cheesy Garlic Chicken recipes!
Chicken Bubble Biscuit Bake Casserole Ingredients
• Explore the key components of this delicious dish!
For the Casserole
- Cooked Chicken – Shredded or diced; this adds protein and flavor, making it a great choice for the Chicken Bubble Biscuit Bake Casserole.
- Cream of Chicken Soup – This forms the creamy base; can use cream of mushroom or cream of celery for a yummy twist.
- Sour Cream – Adds tanginess and creaminess; Greek yogurt can be used for a lighter option.
- Milk – Helps achieve the perfect sauce consistency; any milk type works, or omit for a thicker sauce.
- Frozen Mixed Vegetables – These add nutrients and color; feel free to swap for peas, carrots, corn, or beans based on your preference.
- Garlic Powder – A must for enhancing flavor.
- Onion Powder – Provides additional depth of taste.
- Salt & Pepper – Essential seasonings to taste.
For the Biscuit Topping
- Refrigerated Biscuit Dough – Forms fluffy dumplings once baked; cutting each biscuit into quarters helps with even cooking.
- Shredded Cheese (Cheddar/Mozzarella) – Adds gooey texture and delicious flavor; a blend of cheeses can elevate the dish even further.
- Melted Butter – For brushing on top to promote browning; optional but recommended for an extra layer of flavor.
Step‑by‑Step Instructions for Chicken Bubble Biscuit Bake Casserole
Step 1: Preheat and Prepare
Begin by preheating your oven to 350°F (175°C). While it warms up, generously grease a 9×13-inch baking dish to prevent the Chicken Bubble Biscuit Bake Casserole from sticking. Use butter or cooking spray, ensuring all corners are coated well, which will help in achieving a lovely golden brown during baking.
Step 2: Combine the Filling
In a large mixing bowl, combine the cooked chicken, cream of chicken soup, sour cream, and milk. Stir in the frozen mixed vegetables, garlic powder, onion powder, salt, and pepper until everything is evenly mixed. The mixture should be creamy and well-blended, creating a comforting base for the casserole that will envelop all the delicious flavors.
Step 3: Add Biscuit Pieces
Carefully fold in the quartered biscuit dough pieces into the chicken mixture, ensuring each piece is well-coated. This step is essential as it allows the biscuit to absorb the creamy sauce while baking. You want to achieve a nice, even distribution, so take your time to combine without breaking up the biscuits too much.
Step 4: Pour into Baking Dish
Transfer the combined mixture into your prepared baking dish, spreading it out evenly to ensure uniform cooking. As you do this, ensure that the biscuit pieces are well-distributed throughout the Chicken Bubble Biscuit Bake Casserole, creating delicious, fluffy layers that will rise while baking.
Step 5: Add Cheese and Bake
Sprinkle shredded cheese generously on top of the casserole mixture, which will melt beautifully and create a cheesy golden crust. Cover the dish with foil to keep the moisture in and bake in the preheated oven for 20 minutes, allowing the flavors to meld and the biscuits to start cooking through.
Step 6: Uncover and Continue Baking
After 20 minutes, carefully remove the foil to allow the top to crisp up. Return the casserole to the oven and bake for an additional 10-15 minutes. Watch closely for a golden brown finish and puffy biscuit tops—this visual cue indicates that your Chicken Bubble Biscuit Bake Casserole is perfectly baked and ready to enjoy.
Step 7: Optional Butter Brushing
If you desire an extra layer of flavor, brush melted butter on top during the last few minutes. This will enhance the golden color and add a rich taste to the finished casserole. Once out of the oven, let it cool slightly so the sauce can set before diving into this scrumptious dish.

What to Serve with Chicken Bubble Biscuit Bake Casserole
Imagine the comforting warmth of your kitchen, filled with delicious aromas, as you create the perfect meal companions for this delightful casserole.
- Crispy Side Salad: A fresh mix of greens, tomatoes, and cucumbers with a tangy vinaigrette adds brightness, balancing the rich flavors of the casserole.
- Garlic Breadsticks: These soft and buttery sticks offer a delightful crunch, perfect for sopping up the creamy sauce from the casserole.
- Steamed Broccoli: Tender yet crisp, broccoli provides a nutritious, vibrant contrast to the cozy casserole, making every bite feel wholesome.
- Roasted Sweet Potatoes: Their natural sweetness complements the savory elements of the casserole, creating a lovely balance of flavors on your plate.
- Creamy Coleslaw: A refreshing, crunchy slaw adds texture and a lightness that pairs wonderfully with the casserole’s hearty goodness.
- Herbed Corn on the Cob: Sweet corn, brushed with melted butter and sprinkled with fresh herbs, offers a burst of flavor that ties the entire meal together.
- Homemade Apple Crisp: For dessert, warm apple crisp topped with vanilla ice cream rounds out the meal with a delightful and comforting finish.
- Sparkling Lemonade: A bright and bubbly drink refreshes the palate, making it an inviting complement to this warm, filling casserole.
How to Store and Freeze Chicken Bubble Biscuit Bake Casserole
Fridge: Refrigerate leftovers in an airtight container for up to 4 days. Make sure to allow the casserole to cool before sealing to prevent moisture buildup.
Freezer: For long-term storage, freeze the casserole after baking for up to 2 months. Ensure it’s tightly wrapped in plastic wrap and then aluminum foil for best results.
Reheating: Thaw overnight in the fridge before reheating. Warm it gently in the oven at 350°F (175°C) until heated through, about 20-25 minutes. You can cover with foil to prevent the top from browning too much.
Make-Ahead: You can assemble the Chicken Bubble Biscuit Bake Casserole up to 24 hours in advance. Simply cover and refrigerate it before baking when you’re ready to serve!
Expert Tips for Chicken Bubble Biscuit Bake Casserole
- Mix Thoroughly: Ensure all ingredients are well combined for an even distribution of flavors, making your Chicken Bubble Biscuit Bake Casserole more delicious.
- Avoid Overbaking: Keep an eye on the biscuits as they cook. If they start to brown too quickly, cover with foil to prevent burning.
- Rest Before Serving: Let the casserole rest for a few minutes after baking. This helps the sauce thicken and makes for easier serving.
- Customize Wisely: While adding extras like bacon or veggies can enhance the dish, avoid overloading the casserole, which might affect cooking times and texture.
- Use Fresh Ingredients: Fresh, high-quality ingredients make a noticeable difference in flavor. Choose the best chicken and cheese for a truly comforting casserole.
Chicken Bubble Biscuit Bake Casserole Variations
Feel free to explore these delightful twists to make your Chicken Bubble Biscuit Bake Casserole even more personalized and delicious!
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Cheesy Ranch Version: Mix in ranch seasoning for a zesty flavor boost. It’s a crowd-pleaser that adds a creamy tang everyone will love!
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Buffalo Chicken Twist: Add a splash of buffalo sauce for a spicy kick and swap in mozzarella cheese. This variation will surely fire up your taste buds!
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Veggie Lover’s Bake: Incorporate steamed broccoli, carrots, or peas for added nutrition. This colorful option not only pleases the eye but also the palate!
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Loaded Casserole: Toss in cooked bacon crumbles and garnish with green onions before serving. The smoky flavor of bacon complements the creamy sauce perfectly.
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Turkey Swap: Use leftover turkey after the holidays for a delicious twist. It’s a wonderful way to give new life to your holiday leftovers!
If you’re in the mood for more comfort, don’t forget to check out my Southern Cheesy Chicken and Grilled Chicken Sweet recipes for more delectable options!
Make Ahead Options
These Chicken Bubble Biscuit Bake Casserole is perfect for busy weeknights and meal prep enthusiasts! You can assemble the casserole up to 24 hours in advance by mixing the cooked chicken, cream of chicken soup, sour cream, milk, and seasonings, then folding in the biscuit pieces. Cover and refrigerate to keep it fresh. Just before you’re ready to serve, sprinkle the cheese on top and bake it directly from the fridge, adding a few extra minutes to the baking time to ensure everything is heated through. This method not only saves time but ensures each bite remains just as delicious and comforting for your family!

Chicken Bubble Biscuit Bake Casserole Recipe FAQs
What type of chicken should I use for the casserole?
You can use shredded or diced cooked chicken for the Chicken Bubble Biscuit Bake Casserole. I often recommend rotisserie chicken as it saves time and adds fantastic flavor, but leftover grilled or baked chicken works well too!
How should I store leftovers from the casserole?
Refrigerate any leftovers in an airtight container for up to 4 days. Ensure the casserole has cooled before sealing to avoid moisture buildup, which can make the biscuits soggy.
Can I freeze the Chicken Bubble Biscuit Bake Casserole?
Absolutely! You can freeze the casserole for up to 2 months after baking. Make sure it’s tightly wrapped in plastic wrap followed by aluminum foil to prevent freezer burn. When you’re ready to enjoy it again, simply thaw it overnight in the fridge before reheating.
What can I do if the biscuits brown too quickly while baking?
If you find that the biscuits are browning too fast, you can cover the casserole with foil during the last few minutes of baking. This will help prevent burning while allowing the biscuits to cook through fully.
Are there any dietary considerations for this casserole?
Yes, be mindful of dietary restrictions. For gluten-free options, you can use gluten-free biscuits. Additionally, if there’s a dairy allergy, substituting with dairy-free cream soups and non-dairy milk can also work well. Always check ingredient labels if allergies are a concern!
How can I enhance the flavor of the casserole?
To elevate the taste of your Chicken Bubble Biscuit Bake Casserole, consider mixing in a packet of ranch dressing mix for a cheesy ranch version, or add some buffalo sauce for a spicy kick. You could also enhance it with extra veggies like broccoli or peas for added nutrition!

Heavenly Chicken Bubble Biscuit Bake Casserole for All!
Ingredients
Equipment
Method
- Preheat your oven to 350°F (175°C) and grease a 9x13-inch baking dish.
- In a large bowl, combine cooked chicken, cream of chicken soup, sour cream, and milk. Mix in the frozen vegetables, garlic powder, onion powder, salt, and pepper.
- Fold in quartered biscuit dough pieces until well-coated.
- Transfer to the prepared baking dish, spreading it out evenly.
- Sprinkle shredded cheese on top, cover with foil, and bake for 20 minutes.
- Remove foil and bake for an additional 10-15 minutes until golden brown.
- Optionally brush melted butter on top during the last few minutes of baking.
- Let it cool slightly before serving.

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